A lot has changed since the Ghostbusters last saved the world. Dr. Peter Venkman now hosts a talk show on parapsychology, Dr. Ray Stantz and Winston Zeddemore make a living as entertainers for children's birthday parties, and Dr. Egon Spengler continues to research the effect of human emotions on psycho-magnetic energy fields. However, when Dana Barrett's eight-month-old son becomes the target of demons, she calls the team back from retirement.