1600 Pennsylvania Avenue, the most powerful address in the nation is now the focal point of a homicide investigation. After the discovery of a young woman's slain body at the White House, jaded Washington DC detective Harlan Regis (Snipes) finds himself embroiled in a cover-up that may even reach the highest level of government. With the reluctant assistance of Secret Service agent Nina Chance (Lane), Regis searches for the truth amid a political scandal rife with suspects including National Security Advisor Alvin Jordan (Alda). Soon, Regis and Chance confront a situation far more complex and dangerous than they could have imagined.