This is the story of four female friends who examine their love relationships and do not like what they see. Jane (McDormand), a successful dress designer who has stopped washing hair, is prone to outbursts and is married to a man who might be gay. Franny (Cusack) is a multimillionaire who appears to have the perfect life with her family. Christine (Keener) is building her dream house and writing a screenplay with her husband as their life together is crumbling. And the youngest of the foursome, Olivia (Aniston), is a pot-smoking maid who stalks her ex-lover.